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Human CD47-related genes are present in many Poxviridae including Vaccinia virus CD47 (AAB96477), variola virus CD47 (P33853) and Yaba monkey tumor virus (AB025319). A phylogenetic tree analysis indicated viral CD47 divergence occurred before the divergence of rodents and primates (Hughes 2002). They inserted the CD47 gene into a virus, which was transduced into human and mouse stem cells with no MHC proteins. When these stem cells were transplanted into mismatched mice with normal mice immune systems as well as humanized mouse immune systems, there was no observed rejection. CD47 is similar to these genes: Galectin-3, Dermatopontin, BCAR1 and more. Human Gene CD47 (uc003dwt.1) Description and Page Index Description: Homo sapiens CD47 molecule (CD47), transcript variant 1, mRNA.

Moreover, macrophage phagocytosis rate was significantly increased when co-cultured with HIF-1-deficient breast cancer cells [ 43 ], indicating that HIF-1 plays a pivotal role in regulation of CD47 expression. The gene is located on the long arm of chromosome 1 at location 1q22-q25 on the Crick (negative) strand. The gene is 87,896 bases in length [citation needed]. The encoded protein is 164 amino acids long with a predicted weight of 18.696 kiloDaltons. Function Cd47: Description: CD47 antigen (Rh-related antigen, integrin-associated signal transducer) [Source:MGI Symbol;Acc:MGI:96617] Organism: Mus musculus: Synonym(s) 9130415e20rik, aa407862, ai848868, aw108519, b430305p08rik, iap, integrin-associated protein, itgp: Orthologs(s) 16 orthologs CD47: Description: CD47 molecule [Source:HGNC Symbol;Acc:HGNC:1682] Organism: Homo sapiens: Synonym(s) a8k198, d3dn59, iap, mer6, oa3, q53y71, q96a60: Orthologs(s) 17 orthologs Gene information about ENSG00000196776 / CD47 - CD47 molecule. We use cookies to enhance the usability of our website.

CD47 (HGNC Symbol) Synonyms. IAP, MER6, OA3: Description.

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The encoded protein is 164 amino acids long with a predicted weight of 18.696 kiloDaltons. Function Cd47: Description: CD47 antigen (Rh-related antigen, integrin-associated signal transducer) [Source:MGI Symbol;Acc:MGI:96617] Organism: Mus musculus: Synonym(s) 9130415e20rik, aa407862, ai848868, aw108519, b430305p08rik, iap, integrin-associated protein, itgp: Orthologs(s) 16 orthologs CD47: Description: CD47 molecule [Source:HGNC Symbol;Acc:HGNC:1682] Organism: Homo sapiens: Synonym(s) a8k198, d3dn59, iap, mer6, oa3, q53y71, q96a60: Orthologs(s) 17 orthologs Gene information about ENSG00000196776 / CD47 - CD47 molecule. We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies.

080 - Trillium Therapeutics vs. ALX Oncology? The CD47 Space

Animal Model Lindberg et al. (1996) made observations in gene-targeted mice indicating that integrin-associated protein plays a key role in host defense by participating both in polymorphonuclear migration in response to bacterial infection and in polymorphonuclear activation at extravascular sites. Gene: CD47; CD47 molecule: Aliases: IAP, OA3, MER6 : Location: 3q13.12: Summary: This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. CD47 (integrin-associated protein, IAP) is a ubiquitously expressed cell surface transmembrane glycoprotein interacting with several integrins and regulating their functions.

-0.40. CD47.
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CD47 (CD47 Molecule) is a Protein Coding gene. Diseases associated with CD47 include Hereditary Spherocytosis and Neonatal Meningitis.

Gene WT_Nondiff_2_Control_vs_WT_Nondiff_1_Control-FC 0.15 -2.2 8e-04 0.0054 Cd47 0.13 0.14 0.44 -0.75 0.0059 0.071 -0.88 0.0053 0.012 1.4 0.00048 Proteinerna CD47 och SIRP? är grundläggande för att upprätta ett korrekt antal immunceller, så kallade B-lymfocyter, enligt en ny avhandling. Expression and Regulation of the Cell Surface Proteins CD47 and SIRPα in Resident Expression of weight and aggression regulating genes in Drosophila proteinbearbetning och vikning (CANX, PSENEN) och det integrin-associerade protein, CD47, som modulerar cellaktivering och vidhäftning.
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CD47 functional study in CCA. Introduction. Genome editing or gene 1 Oct 2018 CD47 has been found to be present on leukemic stem cells, but not on normal hematopoietic stem cells, offering an opportunity to target the The MIAP301 monoclonal antibody reacts with mouse CD47 otherwise known as integrin-associated protein (IAP).

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Anti-CD47 Mouse Monoclonal Antibody Purified, BSA-free

development of antisense strategies to locally or globally suppress CD47 gene expression. A translation-blocking CD47 morpholino improves tissue survival in skin flap and hindlimb fixed ischemia models, full thickness skin grafts, and a liver ischemia/reperfusion model of organ transplantation in mice. Furthermore, the benefits of morpholino The up-regulation of CD47 expression is generally epigenetic, whereas gene amplification occurs with low frequency in some cancers. CD47 is a high affinity 27 Dec 2019 Tumors can escape from the immune system by overexpressing CD47 and other checkpoint blockades. CD47 is expressed ubiquitously by all Know comprehensive CD47 protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction. 10 Products The gene CD47 may have Genomic and Proteomic products available from Sigma-Aldrich. 11 Jan 2017 Cluster of differentiation 47 (CD47) (also known as integrin-associated protein) is a ubiquitously expressed glycoprotein of the immunoglobulin 601028 - CD47 ANTIGEN; CD47 - SURFACE ANTIGEN IDENTIFIED BY MONOCLONAL ANTIBODY 1D8; MER6;; INTEGRIN-ASSOCIATED PROTEIN; IAP;; Integrin Associated Protein / IAP (CD47) Antibody Abbexa catalog: abx005485.

"ProbeSetID" "Gene.Symbol" "U3002" "U3004" "U3005

It turned out to be associated in cis with integrin αvβ3 on cytometry.

The gene CD47 may have Genomic and Proteomic products available from Sigma-Aldrich. Gene. CD47. Species Human Transcripts.